Binge eating promotes ethanol self-administration in female rats with a history of intermittent ethanol exposure at adolescence

LEYVA, LEANDRO RUIZ; SALGUERO, AGUSTÍN; VIRGOLINI, MIRIAM BEATRIZ; ROMERO, VERÓNICA LEONOR; MARENGO, LEONARDO; FABIO, MARÍA CAROLINA; MORÓN-HENCHE, IGNACIO; CENDÁN, CRUZ MIGUEL; PAUTASSI, RICARDO MARCOS

DRUG AND ALCOHOL DEPENDENCE

ELSEVIER IRELAND LTD

Año: 2022

0376-8716

ackground: Ethanol drinking begins during adolescence and, particularlywhen occurs in a binge-like pattern, exerts lingering adverse consequences. Pre-clinicalstudies indicate that intermittent ethanol exposure (IEA, a model of repeated ethanolintoxication), or binge eating (BE) can increase subsequent ethanol consumption. It isunknown if the promoting effects of BE upon ethanol drinking are found in female rats andare modulated by IEA at adolescence. This study assessed interactive effects between IEAand BE, upon ethanol drinking. Methods: Female Wistar rats were given 4.0 g/kg ethanol,every other day from postnatal day 25 to 45. At adulthood, they were exposed to sessions inwhich a brief offering of a sizeable portion of highly palatable sugary pills was followed bya 120-min exposure to an ethanol bottle. Results: Exploratory activity and recognitionmemory was not affected by the IEA. Glutathione peroxidase and catalase activity, andlipid peroxidation (measured in blood and brain at